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apalutamide will minimize the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicines which might be CYP3A4 substrates may end up in decrease exposure to those remedies.Minor (one)modafinil will improve the stage o